Vishnu K. Tandon, Anoop K. Awasthi, Kunwar A. Singh, Hardesh K. Maurya and Sanjay K. Gautam
Favorskii type rearrangement of cyclic α-bromo ketones 2 is promoted by NiCl2 in refluxing methanol, giving the rearranged carboxylic acid ester 3 in excellent yields. The reaction of 4-bromo-2,3,4,5-tetrahydronaphth [2,1-b]oxepin-5-one (5) and its regioisomer 8 with NiCl2 in MeOH resulted in Favorskii rearranged carboxylic acid esters 6 and 9 respectively.
Favorskii type rearrangement of cyclic α-bromo ketones 2 is promoted by NiCl2 in refluxing methanol, giving the rearranged carboxylic acid ester 3 in excellent yields. The reaction of 4-bromo-2,3,4,5-tetrahydronaphth [2,1-b]oxepin-5-one (5) and its regioisomer 8 with NiCl2 in MeOH resulted in Favorskii rearranged carboxylic acid esters 6 and 9 respectively.
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