Pushyamitra Mishra, Sandeep Kumar, Hardesh K. Maurya, Sanjay K. Gautam, Brijesh Kumar, Vishnu K. Tandon,* and Vishnu Ji Ram*
Abstract
One-pot regioselective synthesis of 2,6-diarylpyrimidines (4), 2,6-disubstituted pyridines (5 and 6), 5-aryl-3-cyanomethyl-1H-pyrazoles (7) through base catalyzed ring transformation of suitably functionalized 2H-pyran-2-ones
by arylamidines, cyanamide, ammonium carbonate, hydrazines respectively
has been developed. Our synthetic approach opened a new avenue for the
regioselective synthesis of 2,6-diarylpyrimidines and 2,6-disubstituted
pyridines and cyanomethylpyrazoles. The procedure is very simple,
efficient and economically viable. The protocol provides an efficient
methodology for the preparation of new class of medicinally useful and
highly functionalized azines and azoles from single precursor 2H-pyran-2-ones.
