Monday, February 3, 2014

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

Tetrahedron LettersVolume 55, Issue 105 March 2014Pages 1715-1719
Hardesh K Maurya, Atul Gupta
Medicinal Chemistry Department, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Kukrail Road, Lucknow-226015, India
http://dx.doi.org/10.1016/j.tetlet.2014.01.095

Abstract

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.