Facile and Efficient Synthesis of 1,4-Benzodiazepines from 1,4-Naphthoquinones

Heterocycles, Volume 76, Issue 2 ( November, 1, 2008 ), Pages 1007-1010
DOI: 10.3987/COM-08-S(N)63

Vishnu K. Tandon and Hardesh K. Maurya
Concise intramolecular cyclization reaction of 2,3-diamino-1,4-dihydro-naphthalenediones 4 and 7 in anhydrous K2CO3 /Et3N and EtOH yielded novel 1,4-benzodiazepines 5 and 6 fused with 1,4-naphthoquinone nucleus.