InBr3- and AgOTf-catalyzed Beckmann rearrangement of (E)-benzoheterocyclic oximes

1. Journal of Heterocyclic Chemistry

1. Vishnu K. Tandon^*, 
2. Anoop K. Awasthi,
3. Hardesh K. Maurya, 
4. Pushyamitra Mishra

1. DOI: 10.1002/jhet.438 

1. Beckmann rearrangement of (E)-4-chromanone oxime, (E)-5-oximino-3,4-dihydro-1(2H)-benzoxepines, and (E)-5-oximino-3,4-dihydro-1(2H)-benzothiepine are catalyzed by InBr₃ and AgOTf in refluxing acetonitrile resulting in the formation of pharmaceutically active heterocycles benzoxazepin-4-one, 5-oxo-benzoxazocines, and 5-oxo-benzothiazocine derivative, respectively, in excellent yield. J. Heterocyclic Chem., (2012).