Synthesis and evaluation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones that potently induce apoptosis in cancer cells

Vishnu K. Tandon,   Hardesh K. Maurya,   Sandeep Kumar,  Aijaz Rashid and   Dulal Panda  

RSC Adv., 2014, 4, 12441-12447

Full TextDOI: 10.1039/C3RA47720G
This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by an environmentally benign short synthetic route with the goal of finding 1,4-naphthoquinone derivatives that induce apoptosis in cancer cells. We have identified three most active naphthoquinones 10, 12 and 15 that potently induce apoptosis in human cervical carcinoma (HeLa) cells. One of these three compounds perturbed both microtubule and actin filaments.

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

Tetrahedron Letters, Volume 55, Issue 10, 5 March 2014, Pages 1715-1719
Hardesh K Maurya, Atul Gupta
Medicinal Chemistry Department, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Kukrail Road, Lucknow-226015, India
http://dx.doi.org/10.1016/j.tetlet.2014.01.095

Abstract

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.